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KMID : 0369819970270010023
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Jorunal of Korean Pharmaceutical Sciences
1997 Volume.27 No. 1 p.23 ~ p.27
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Effect of L - arginine on the Stability of Omeprazole
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이은진/Lee EJ
한경두/신희종/김정우/김종국/Han KD/Shin HJ/Kim JW/Kim CK
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Abstract
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To investigate the effect of L-arginine as stabilizing agent for omeprazole, the degradation rate constant of omeprazole in aqueous solution was determined at 30, 40 and 50?C with various ratios of L-arginine to omeprazole. The pH of omeprazole solutions was also determined. As the amount of L-arginine increased, the pH of omeprazole solution also increased, and the solution appeared to be more stable. The omeprazole in aqueous solution could be stabilized by more than 15:1 molar ratio of L-arginine to omeprazole. The stability of omeprazole in commercial products using L-arginine or sodium phosphate dibasic as stabilizing agent was investigated. Among the commercial products, the omeprazole product prepared with L-arginine (molar ratio of L-arginine to omeprazole, 20:1) was most stable.
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KEYWORD
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Omeprazole, Stability, L-arginine, Molar ratio, Degradation rate constant, pH
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